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MOTS-c is a mitochondria-derived peptide made up of 16 amino acids, encoded within mitochondrial DNA - which sets it apart from most peptides that originate from the nuclear genome.
A Signal Between Mitochondria and the Cell
MOTS-c is studied as a molecule that acts as a signal between mitochondria and the rest of the cell, participating in the regulation of energy metabolism. This communicative role makes it an interesting model for research into mitochondrial bioenergetics.
What Are Mitochondrial-Derived Peptides (MDPs)
MOTS-c belongs to a group known as mitochondrial-derived peptides - a relatively recently discovered class of molecules encoded within mitochondrial rather than nuclear DNA. This group also includes other peptides such as Humanin, and their discovery has changed the long-standing view of mitochondria as merely the cell's 'powerhouses,' opening up a research field into mitochondrial signaling toward the nucleus and the rest of the organism.
Discovery of the MOTS-c Gene Within the Mitochondrial 12S rRNA Gene
What makes MOTS-c particularly interesting is how it was discovered - scientists identified it within the sequence of the gene for 12S ribosomal RNA (rRNA), a region of mitochondrial DNA long thought to serve only a structural role in synthesizing mitochondrial proteins, not to encode a functional peptide of its own. This discovery prompted researchers to reconsider how many more 'hidden' peptides might be encoded within regions of the mitochondrial genome that were traditionally not considered coding regions.
Research Context of Aging and Energy
Due to its role in energy pathways, MOTS-c is often studied alongside other mitochondria-related materials such as SS-31 and Humanin, which also fall under the broader category of mitochondrial bioenergetics.
Available Specifications
Peptiva offers MOTS-c in two concentrations, 10 mg and 20 mg, in both laboratory formats - vial and research pen.
Limitations of the Available Evidence
As with most mitochondria-derived peptides, most of the available literature relates to preclinical models. A thorough review of the source literature is recommended before including it in a research protocol.
The content of this article is intended for general research context and does not constitute medical advice or a recommendation for use in humans or animals.