{"product_id":"humanin","title":"Research Compound Humanin","description":"\u003cp\u003e\u003cstrong\u003eResearch Compound Humanin\u003c\/strong\u003e is a laboratory material for analytical and in vitro work.\u003c\/p\u003e\u003ch2\u003eWhat is humanin?\u003c\/h2\u003e\u003cp\u003eHumanin is a 24-amino-acid peptide (MAPRGFSCLLLLTSEIDLPVKRRA) with a molecular weight of approximately 2.7 kDa. It is encoded within the mitochondrial gene for 16S ribosomal RNA and was the first mitochondrial-derived peptide to be discovered.\u003c\/p\u003e\u003ch2\u003eResearch background\u003c\/h2\u003e\u003cp\u003eHumanin was discovered in 2001 by Ikuo Nishimoto's group in Japan while searching for genes that protect neurons from amyloid-related toxicity in cellular models. Related peptides such as \u003ca href=\"\/en\/products\/mots-c\"\u003eMOTS-c\u003c\/a\u003e were found later, creating an entire research field.\u003c\/p\u003e\u003ch2\u003eMechanism and scientific context\u003c\/h2\u003e\u003cp\u003eHumanin acts both inside and outside the cell. Intracellularly it is associated with inhibition of the pro-apoptotic protein Bax; extracellularly with the FPRL1 receptor and a trimeric receptor complex that includes gp130. The literature also frequently uses the analogue HNG (serine-to-glycine substitution at position 14), which shows greater activity in models.\u003c\/p\u003e\u003ch2\u003eMain research areas\u003c\/h2\u003e\u003cul\u003e\u003cli\u003emitochondrial-derived peptides\u003c\/li\u003e\u003cli\u003eapoptotic signalling and Bax\u003c\/li\u003e\u003cli\u003ecellular stress response\u003c\/li\u003e\u003cli\u003eneuronal cell models\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eLevel of evidence\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003ePredominantly preclinical.\u003c\/strong\u003e Clinical benefit in humans has not been established.\u003c\/p\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use only:\u003c\/strong\u003e for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our \u003ca href=\"\/en\/pages\/coa-vodic\"\u003eCOA guide\u003c\/a\u003e.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"10 mg \/ Lyophilized vial","offer_id":56971451990356,"sku":"PEP-HUMANIN-10MG-AMP","price":119.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ Research dispenser","offer_id":56971452023124,"sku":"PEP-HUMANIN-10MG-PEN","price":131.75,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/peptiva-2026-humanin-10mg-ampulica.png?v=1787605989","url":"https:\/\/peptiva.com.hr\/en-eu\/products\/humanin","provider":"Peptiva peptides","version":"1.0","type":"link"}