{"product_id":"tb-500","title":"Research Compound TB-500","description":"\u003cp\u003e\u003cstrong\u003eResearch Compound TB-500\u003c\/strong\u003e is a laboratory material for analytical and in vitro work, available as a lyophilised vial or a research dispenser.\u003c\/p\u003e\u003ch2\u003eWhat is TB-500?\u003c\/h2\u003e\u003cp\u003eTB-500 is a commercial designation for research materials related to thymosin beta-4 (Tβ4). Native Tβ4 is a 43-amino-acid peptide with a molecular weight of approximately 4.9 kDa and one of the most abundant intracellular peptides in many cell types. Both the full sequence and shorter synthetic fragments, such as the 17–23 region (LKKTETQ) associated with actin binding, are sold under the TB-500 name, so the declared identity should always be checked in the batch specification.\u003c\/p\u003e\u003ch2\u003eResearch background\u003c\/h2\u003e\u003cp\u003eThymosin beta-4 was originally described in studies of thymic extracts in the 1980s and was later recognised as the main protein that sequesters monomeric G-actin in cells. It has since been studied in models of cell migration, angiogenesis and tissue remodelling, including dermal and cardiovascular animal models.\u003c\/p\u003e\u003ch2\u003eMechanism and scientific context\u003c\/h2\u003e\u003cp\u003eTβ4 sequesters G-actin and thereby influences the balance between monomeric and polymerised actin, which underlies cell motility. In experimental models it is also associated with angiogenic signalling, progenitor cell differentiation and modulation of inflammatory mediators. Data for native Tβ4 cannot automatically be attributed to every material labelled TB-500.\u003c\/p\u003e\u003ch2\u003eMain research areas\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eactin and cytoskeletal dynamics\u003c\/li\u003e\u003cli\u003ecell migration and adhesion\u003c\/li\u003e\u003cli\u003eangiogenesis and endothelial models\u003c\/li\u003e\u003cli\u003edermal and epithelial models\u003c\/li\u003e\u003cli\u003ecardiovascular animal models\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eLevel of evidence\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003ePredominantly preclinical.\u003c\/strong\u003e For native Tβ4 there is extensive cellular and animal literature and a limited number of clinical trials of specific preparations; for materials labelled TB-500 there are no quality clinical data.\u003c\/p\u003e\u003ch2\u003eRelated research materials\u003c\/h2\u003e\u003cp\u003eTB-500 is frequently discussed alongside \u003ca href=\"\/en\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e and is also available as \u003ca href=\"\/en\/products\/bpc-157-tb-500-mix\"\u003eBPC-157 \/ TB-500 Mix\u003c\/a\u003e and as a component of \u003ca href=\"\/en\/products\/glow\"\u003eGLOW\u003c\/a\u003e and \u003ca href=\"\/en\/products\/klow\"\u003eKLOW\u003c\/a\u003e.\u003c\/p\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use only:\u003c\/strong\u003e for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our \u003ca href=\"\/en\/pages\/coa-vodic\"\u003eCOA guide\u003c\/a\u003e.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"5 mg \/ Lyophilized vial","offer_id":56971455299924,"sku":"PEP-TB500-5MG-AMP","price":38.25,"currency_code":"EUR","in_stock":true},{"title":"5 mg \/ Research dispenser","offer_id":56971455332692,"sku":"PEP-TB500-5MG-PEN","price":51.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ Lyophilized vial","offer_id":56971455365460,"sku":"PEP-TB500-10MG-AMP","price":72.25,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ Research dispenser","offer_id":56971455398228,"sku":"PEP-TB500-10MG-PEN","price":85.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/peptiva-2026-tb-500-5mg-ampulica.png?v=1787606049","url":"https:\/\/peptiva.com.hr\/en-eu\/products\/tb-500","provider":"Peptiva peptides","version":"1.0","type":"link"}