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Somatropin, commonly searched as HGH or recombinant human growth hormone, is a protein corresponding to the principal form of endogenous growth hormone. In research it is used as a reference material for studies of the growth hormone receptor, JAK2/STAT signaling and the relationship between GH and the IGF-1 axis.
How does GH signaling work?
Binding to the growth hormone receptor promotes receptor dimerization and activates intracellular pathways. Frequently studied routes include JAK2/STAT, MAPK and PI3K/AKT. Part of the downstream response involves changes in IGF-1 expression, which is why somatropin is usually interpreted within the broader GH/IGF-1 axis.
What is measured in the laboratory?
- receptor and signaling-protein phosphorylation
- target-gene expression
- cell proliferation and differentiation
- protein integrity, aggregation and stability
- concentration-response relationships
Why do identity and handling matter?
Somatropin is a folded protein whose behavior can be affected by aggregation, temperature and sample preparation. Declared mass alone does not confirm identity or biological activity. Chromatography, mass spectrometry and functional assays may be combined according to the research objective.
Related laboratory material
See the neutrally labeled GH Complex laboratory reference material.
Further reading
PubMed: somatropin, GH receptor and IGF-1
RESEARCH USE ONLY: This educational content concerns laboratory and scientific research. Peptiva research materials are not medicines and are not intended for use in humans or animals.