{"title":"Melanocortin system","description":"\u003cp\u003eResearch peptides studied in the context of melanocortin receptors and neuroendocrine signalling in cellular and preclinical models.\u003c\/p\u003e","products":[{"product_id":"melanotan-2","title":"Research Compound Melanotan II","description":"\u003cp\u003e\u003cstrong\u003eResearch Compound Melanotan 2\u003c\/strong\u003e is a laboratory material for analytical and in vitro work.\u003c\/p\u003e\u003ch2\u003eWhat is Melanotan 2?\u003c\/h2\u003e\u003cp\u003eMelanotan 2 (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH) with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 and a molecular weight of approximately 1024 Da. Cyclisation and the substitution of L-phenylalanine with its D-form increase stability relative to native α-MSH.\u003c\/p\u003e\u003ch2\u003eResearch background\u003c\/h2\u003e\u003cp\u003eThe molecule was developed at the University of Arizona in the 1980s and 1990s as part of research into melanocortin analogues. The same research line later produced \u003ca href=\"\/en\/products\/bremelanotid-pt-141\"\u003ebremelanotide (PT-141)\u003c\/a\u003e, which is structurally related but not the same molecule.\u003c\/p\u003e\u003ch2\u003eMechanism and scientific context\u003c\/h2\u003e\u003cp\u003eMT-II is a non-selective agonist of several melanocortin receptors (MC1R, MC3R, MC4R and MC5R). In experimental models it is therefore associated simultaneously with melanogenesis (MC1R), central neuroendocrine signalling (MC3R\/MC4R) and other pathways. This lack of selectivity makes it a useful tool for comparison with more selective ligands.\u003c\/p\u003e\u003ch2\u003eMain research areas\u003c\/h2\u003e\u003cul\u003e\u003cli\u003emelanocortin receptor pharmacology\u003c\/li\u003e\u003cli\u003ereceptor selectivity\u003c\/li\u003e\u003cli\u003emelanogenesis in cellular models\u003c\/li\u003e\u003cli\u003ecentral melanocortin signalling\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eLevel of evidence\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003ePreclinical and limited experimental human literature.\u003c\/strong\u003e The molecule is not an approved medicine, and its safety profile has not been adequately established.\u003c\/p\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use only:\u003c\/strong\u003e for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our \u003ca href=\"\/en\/pages\/coa-vodic\"\u003eCOA guide\u003c\/a\u003e.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"10 mg \/ Lyophilized vial","offer_id":56971454579028,"sku":"PEP-MELANOTAN2-10MG-AMP","price":29.75,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ Research dispenser","offer_id":56971454611796,"sku":"PEP-MELANOTAN2-10MG-PEN","price":42.5,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/peptiva-2026-melanotan-2-10mg-ampulica.png?v=1787606018"},{"product_id":"kisspeptin","title":"Research Compound Kisspeptin","description":"\u003cp\u003e\u003cstrong\u003eResearch Compound Kisspeptin\u003c\/strong\u003e is a laboratory material for analytical and in vitro work. The exact declared peptide form is stated in the batch specification.\u003c\/p\u003e\u003ch2\u003eWhat is kisspeptin?\u003c\/h2\u003e\u003cp\u003eKisspeptins are a family of peptides produced by cleavage of the protein encoded by the KISS1 gene. The main forms are kisspeptin-54 (also known as metastin), kisspeptin-14, -13 and -10. All share the same C-terminal decapeptide, which is sufficient for receptor activation.\u003c\/p\u003e\u003ch2\u003eResearch background\u003c\/h2\u003e\u003cp\u003eThe KISS1 gene was discovered in 1996 in Hershey, Pennsylvania, as a suppressor of melanoma metastasis, which gave it its name. Only in 2003 did research into the genetics of puberty show that mutations in its receptor disrupt the reproductive axis, moving kisspeptin to the centre of reproductive neuroendocrinology.\u003c\/p\u003e\u003ch2\u003eMechanism and scientific context\u003c\/h2\u003e\u003cp\u003eKisspeptin activates the KISS1R receptor (formerly GPR54), a G-protein-coupled receptor expressed on hypothalamic GnRH neurons. Activation stimulates GnRH release and, consequently, LH and FSH release from the pituitary. Kisspeptin is therefore considered a key upstream control point of the reproductive axis.\u003c\/p\u003e\u003ch2\u003eMain research areas\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eKISS1R signalling\u003c\/li\u003e\u003cli\u003eGnRH neurons\u003c\/li\u003e\u003cli\u003ethe LH\/FSH axis\u003c\/li\u003e\u003cli\u003emetastasis biology (the original context of discovery)\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eLevel of evidence\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003ePreclinical and experimental human data exist\u003c\/strong\u003e from research studies. Kisspeptin is not an approved medicine, and these data do not confirm the properties of this material.\u003c\/p\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cp\u003eSee the \u003ca href=\"\/en\/collections\/reproduktivna-endokrinologija\"\u003eReproductive endocrinology\u003c\/a\u003e collection and the materials \u003ca href=\"\/en\/products\/hcg-istrazivacki-spoj\"\u003eHCG\u003c\/a\u003e and \u003ca href=\"\/en\/products\/hmg-istrazivacki-spoj\"\u003eHMG\u003c\/a\u003e.\u003c\/p\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use only:\u003c\/strong\u003e for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our \u003ca href=\"\/en\/pages\/coa-vodic\"\u003eCOA guide\u003c\/a\u003e.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"10 mg \/ Lyophilized vial","offer_id":56971454021972,"sku":"PEP-KISSPEPTIN-10MG-AMP","price":55.25,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ Research dispenser","offer_id":56971454054740,"sku":"PEP-KISSPEPTIN-10MG-PEN","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/peptiva-2026-kisspeptin-10mg-ampulica.png?v=1787605989"},{"product_id":"pt-compound-10mg","title":"PT Compound 10 mg (For Lab Use)","description":"\u003cp\u003e\u003cstrong\u003ePT Compound 10 mg\u003c\/strong\u003e is a cyclic peptide research material intended for analytical and in vitro studies of receptor signalling.\u003c\/p\u003e\u003ch2\u003eResearch context\u003c\/h2\u003e\u003cp\u003eIts compact cyclic structure makes this specimen suitable for research into structure-activity relationships, peptide stability and selective binding to receptor subtypes.\u003c\/p\u003e\u003ch2\u003eAreas of analysis\u003c\/h2\u003e\u003cul\u003e\u003cli\u003emelanocortin receptor signalling\u003c\/li\u003e\u003cli\u003estructure-activity relationships of cyclic peptides\u003c\/li\u003e\u003cli\u003ereceptor selectivity\u003c\/li\u003e\u003cli\u003estability and degradation of the peptide specimen\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eAnalytical note\u003c\/h2\u003e\u003cp\u003eSmall changes to terminal groups or cyclic structure can significantly alter analytical and receptor profiles, making specimen identity and batch documentation essential.\u003c\/p\u003e\u003ch2\u003eSpecification\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eQuantity: 10 mg\u003c\/li\u003e\u003cli\u003eFormats: vial and research dispenser\u003c\/li\u003e\u003c\/ul\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use:\u003c\/strong\u003e exclusively for laboratory, analytical and in vitro research. Not for use in humans or animals and not a medicine.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"Bočica","offer_id":57391849308500,"sku":"PEP-PTC10-10MG-VIAL","price":38.25,"currency_code":"EUR","in_stock":true},{"title":"Istraživački dozator","offer_id":57391849341268,"sku":"PEP-PTC10-10MG-DISP","price":51.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/pt-compound-10mg.png?v=1790965548"},{"product_id":"oxt-nonapeptide-5mg","title":"OXT Nonapeptide 5 mg (Lab Use Only)","description":"\u003cp\u003e\u003cstrong\u003eOXT Nonapeptide 5 mg\u003c\/strong\u003e is a cyclic nonapeptide research material intended for studies of neuroendocrine and calcium-dependent receptor signalling.\u003c\/p\u003e\u003ch2\u003eResearch context\u003c\/h2\u003e\u003cp\u003eThe specimen contains nine amino-acid residues and an intramolecular bond that stabilises the cyclic part of the structure. It is suitable for analysing relationships between peptide conformation, receptor binding and downstream cellular response.\u003c\/p\u003e\u003ch2\u003eAreas of analysis\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eG-protein-coupled receptor signalling\u003c\/li\u003e\u003cli\u003ephospholipase C and intracellular calcium\u003c\/li\u003e\u003cli\u003eneuroendocrine cell models\u003c\/li\u003e\u003cli\u003estability of cyclic nonapeptides\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eAnalytical note\u003c\/h2\u003e\u003cp\u003eDisulfide structure and correct folding are important to the analytical profile. Oxidation, storage and preparation conditions can affect specimen stability.\u003c\/p\u003e\u003ch2\u003eSpecification\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eQuantity: 5 mg\u003c\/li\u003e\u003cli\u003eFormats: vial and research dispenser\u003c\/li\u003e\u003c\/ul\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use:\u003c\/strong\u003e exclusively for laboratory, analytical and in vitro research. Not for use in humans or animals and not a medicine.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"Bočica","offer_id":57391853699412,"sku":"PEP-OXTN5-5MG-VIAL","price":38.25,"currency_code":"EUR","in_stock":true},{"title":"Istraživački dozator","offer_id":57391853732180,"sku":"PEP-OXTN5-5MG-DISP","price":51.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/oxt-nonapeptide-5mg.png?v=1790965554"}],"url":"https:\/\/peptiva.com.hr\/en\/collections\/melanokortinski-sustav.oembed","provider":"Peptiva peptides","version":"1.0","type":"link"}