{"title":"Reproductive endocrinology","description":"\u003cp\u003eResearch materials studied in the context of gonadotropin and reproductive hormone signalling in cellular and preclinical models.\u003c\/p\u003e","products":[{"product_id":"kisspeptin","title":"Research Compound Kisspeptin","description":"\u003cp\u003e\u003cstrong\u003eResearch Compound Kisspeptin\u003c\/strong\u003e is a laboratory material for analytical and in vitro work. The exact declared peptide form is stated in the batch specification.\u003c\/p\u003e\u003ch2\u003eWhat is kisspeptin?\u003c\/h2\u003e\u003cp\u003eKisspeptins are a family of peptides produced by cleavage of the protein encoded by the KISS1 gene. The main forms are kisspeptin-54 (also known as metastin), kisspeptin-14, -13 and -10. All share the same C-terminal decapeptide, which is sufficient for receptor activation.\u003c\/p\u003e\u003ch2\u003eResearch background\u003c\/h2\u003e\u003cp\u003eThe KISS1 gene was discovered in 1996 in Hershey, Pennsylvania, as a suppressor of melanoma metastasis, which gave it its name. Only in 2003 did research into the genetics of puberty show that mutations in its receptor disrupt the reproductive axis, moving kisspeptin to the centre of reproductive neuroendocrinology.\u003c\/p\u003e\u003ch2\u003eMechanism and scientific context\u003c\/h2\u003e\u003cp\u003eKisspeptin activates the KISS1R receptor (formerly GPR54), a G-protein-coupled receptor expressed on hypothalamic GnRH neurons. Activation stimulates GnRH release and, consequently, LH and FSH release from the pituitary. Kisspeptin is therefore considered a key upstream control point of the reproductive axis.\u003c\/p\u003e\u003ch2\u003eMain research areas\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eKISS1R signalling\u003c\/li\u003e\u003cli\u003eGnRH neurons\u003c\/li\u003e\u003cli\u003ethe LH\/FSH axis\u003c\/li\u003e\u003cli\u003emetastasis biology (the original context of discovery)\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eLevel of evidence\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003ePreclinical and experimental human data exist\u003c\/strong\u003e from research studies. Kisspeptin is not an approved medicine, and these data do not confirm the properties of this material.\u003c\/p\u003e\u003ch2\u003eRelated\u003c\/h2\u003e\u003cp\u003eSee the \u003ca href=\"\/en\/collections\/reproduktivna-endokrinologija\"\u003eReproductive endocrinology\u003c\/a\u003e collection and the materials \u003ca href=\"\/en\/products\/hcg-istrazivacki-spoj\"\u003eHCG\u003c\/a\u003e and \u003ca href=\"\/en\/products\/hmg-istrazivacki-spoj\"\u003eHMG\u003c\/a\u003e.\u003c\/p\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use only:\u003c\/strong\u003e for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our \u003ca href=\"\/en\/pages\/coa-vodic\"\u003eCOA guide\u003c\/a\u003e.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"10 mg \/ Lyophilized vial","offer_id":56971454021972,"sku":"PEP-KISSPEPTIN-10MG-AMP","price":55.25,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ Research dispenser","offer_id":56971454054740,"sku":"PEP-KISSPEPTIN-10MG-PEN","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/peptiva-2026-kisspeptin-10mg-ampulica.png?v=1787605989"},{"product_id":"hmg-reference-standard-75iu","title":"HMG Reference Standard 75 IU (Research Grade)","description":"\u003cp\u003e\u003cstrong\u003eHMG Reference Standard 75 IU\u003c\/strong\u003e is a glycoprotein reference material intended for laboratory characterisation and comparative in vitro analysis.\u003c\/p\u003e\u003ch2\u003eResearch context\u003c\/h2\u003e\u003cp\u003eThe standard is used in studies of complex hormonal systems, receptor biology and the standardisation of biological activity. Activity is expressed in international units, enabling comparison between batches and analytical procedures.\u003c\/p\u003e\u003ch2\u003eAreas of analysis\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eglycoprotein structure and heterogeneity\u003c\/li\u003e\u003cli\u003ereceptor signalling in experimental models\u003c\/li\u003e\u003cli\u003ecomparison of biological activity\u003c\/li\u003e\u003cli\u003edevelopment and verification of analytical methods\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eAnalytical note\u003c\/h2\u003e\u003cp\u003eGlycosylation and the ratio of active components can affect the analytical profile, so complete characterisation may require several complementary methods.\u003c\/p\u003e\u003ch2\u003eSpecification\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eQuantity: 75 IU\u003c\/li\u003e\u003cli\u003eFormats: vial and research dispenser\u003c\/li\u003e\u003c\/ul\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use:\u003c\/strong\u003e exclusively for laboratory, analytical and in vitro research. Not for use in humans or animals and not a medicine.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"Bočica","offer_id":57391847932244,"sku":"PEP-HMGRS75-75IU-VIAL","price":42.5,"currency_code":"EUR","in_stock":true},{"title":"Istraživački dozator","offer_id":57391847965012,"sku":"PEP-HMGRS75-75IU-DISP","price":55.25,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/hmg-reference-75iu.png?v=1790965495"},{"product_id":"cg-peptide-5000iu","title":"CG Peptide 5000 IU (Research Only)","description":"\u003cp\u003e\u003cstrong\u003eCG Peptide 5000 IU\u003c\/strong\u003e is a glycoprotein research material for analytical and in vitro work, with activity expressed in international units.\u003c\/p\u003e\u003ch2\u003eResearch context\u003c\/h2\u003e\u003cp\u003eThe material is intended for studying receptor signalling, structure-activity relationships and the analytical characterisation of complex glycoprotein specimens.\u003c\/p\u003e\u003ch2\u003eAreas of analysis\u003c\/h2\u003e\u003cul\u003e\u003cli\u003ereceptor binding and secondary messengers\u003c\/li\u003e\u003cli\u003eglycosylation and structural heterogeneity\u003c\/li\u003e\u003cli\u003eimmunochemical detection methods\u003c\/li\u003e\u003cli\u003ecomparison of activity between batches\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eAnalytical note\u003c\/h2\u003e\u003cp\u003eThe biological activity of such materials depends on preserved structure and glycosylation profile. A single purity method does not provide a complete picture of specimen identity and activity.\u003c\/p\u003e\u003ch2\u003eSpecification\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eQuantity: 5000 IU\u003c\/li\u003e\u003cli\u003eFormats: vial and research dispenser\u003c\/li\u003e\u003c\/ul\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use:\u003c\/strong\u003e exclusively for laboratory, analytical and in vitro research. Not for use in humans or animals and not a medicine.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"Bočica","offer_id":57391849242964,"sku":"PEP-CGP5000-5000IU-VIAL","price":38.25,"currency_code":"EUR","in_stock":true},{"title":"Istraživački dozator","offer_id":57391849275732,"sku":"PEP-CGP5000-5000IU-DISP","price":51.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/cg-peptide-5000iu.png?v=1790965506"},{"product_id":"oxt-nonapeptide-5mg","title":"OXT Nonapeptide 5 mg (Lab Use Only)","description":"\u003cp\u003e\u003cstrong\u003eOXT Nonapeptide 5 mg\u003c\/strong\u003e is a cyclic nonapeptide research material intended for studies of neuroendocrine and calcium-dependent receptor signalling.\u003c\/p\u003e\u003ch2\u003eResearch context\u003c\/h2\u003e\u003cp\u003eThe specimen contains nine amino-acid residues and an intramolecular bond that stabilises the cyclic part of the structure. It is suitable for analysing relationships between peptide conformation, receptor binding and downstream cellular response.\u003c\/p\u003e\u003ch2\u003eAreas of analysis\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eG-protein-coupled receptor signalling\u003c\/li\u003e\u003cli\u003ephospholipase C and intracellular calcium\u003c\/li\u003e\u003cli\u003eneuroendocrine cell models\u003c\/li\u003e\u003cli\u003estability of cyclic nonapeptides\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eAnalytical note\u003c\/h2\u003e\u003cp\u003eDisulfide structure and correct folding are important to the analytical profile. Oxidation, storage and preparation conditions can affect specimen stability.\u003c\/p\u003e\u003ch2\u003eSpecification\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eQuantity: 5 mg\u003c\/li\u003e\u003cli\u003eFormats: vial and research dispenser\u003c\/li\u003e\u003c\/ul\u003e\u003chr\u003e\u003cp\u003e\u003cstrong\u003eResearch use:\u003c\/strong\u003e exclusively for laboratory, analytical and in vitro research. Not for use in humans or animals and not a medicine.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"Bočica","offer_id":57391853699412,"sku":"PEP-OXTN5-5MG-VIAL","price":38.25,"currency_code":"EUR","in_stock":true},{"title":"Istraživački dozator","offer_id":57391853732180,"sku":"PEP-OXTN5-5MG-DISP","price":51.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/oxt-nonapeptide-5mg.png?v=1790965554"}],"url":"https:\/\/peptiva.com.hr\/en\/collections\/reproduktivna-endokrinologija.oembed","provider":"Peptiva peptides","version":"1.0","type":"link"}