{"product_id":"pe-22-28","title":"PE-22-28","description":"\u003ch2\u003eWhat is PE-22-28?\u003c\/h2\u003e\n\u003cp\u003ePE-22-28 is a short synthetic peptide derived from the 22–28 region of the spadin peptide. It is studied in \u003cstrong\u003epreclinical\u003c\/strong\u003e neurobiological research, primarily in the context of the \u003cstrong\u003eTREK-1\u003c\/strong\u003e potassium channel and the regulation of neuronal excitability.\u003c\/p\u003e\n\u003cp\u003ePE-22-28 should be distinguished from original spadin and its other analogues: results for one compound do not automatically confirm the properties of others.\u003c\/p\u003e\n\u003ch2\u003eMechanism and Scientific Context\u003c\/h2\u003e\n\u003cp\u003eTREK-1, also known as KCNK2, belongs to the family of two-pore domain potassium channels. It participates in regulating membrane potential and cellular responses to various stimuli.\u003c\/p\u003e\n\u003cp\u003ePE-22-28 is investigated as an inhibitor of the TREK-1 channel. Altering the activity of this channel can influence the electrical properties of neurons and related signaling processes in experimental systems.\u003c\/p\u003e\n\u003cp\u003ePreclinical work on spadin and its derivatives includes behavioral models related to depression research. Such findings do not constitute proof of antidepressant efficacy of PE-22-28 in humans.\u003c\/p\u003e\n\u003ch2\u003eMain Research Areas\u003c\/h2\u003e\n\u003cul\u003e\n\n\u003cli\u003eTREK-1 potassium channel and its regulation\u003c\/li\u003e\n\n\u003cli\u003emembrane potential and neuronal excitability\u003c\/li\u003e\n\n\u003cli\u003estructure-activity relationship of spadin derivatives\u003c\/li\u003e\n\n\u003cli\u003ecellular signaling processes related to neuronal plasticity\u003c\/li\u003e\n\n\u003cli\u003epreclinical behavioral models related to stress response\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003ch2\u003eHow to interpret research data?\u003c\/h2\u003e\n\u003cp\u003eLiterature on PE-22-28 should be read according to the exact identity of the peptide tested and the type of evidence. Results from electrophysiological experiments, cell cultures, animal models, and controlled clinical studies do not carry equal weight.\u003c\/p\u003e\n\u003cp\u003eEspecially important are the peptide sequence, concentration, model used, duration of observation, control group, and independent reproducibility of results. Behavioral changes in an animal model cannot be equated with improved mood or treatment of depression in humans.\u003c\/p\u003e\n\u003cp\u003eData for spadin or its other derivatives should not be attributed to the PE-22-28 compound without verification.\u003c\/p\u003e\n\u003ch2\u003eAvailable Peptiva variants\u003c\/h2\u003e\n\u003cul\u003e\n\n\u003cli\u003e5 mg · Vial\u003c\/li\u003e\n\n\u003cli\u003e5 mg · Research dispenser\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003cp\u003eYou select the available format as a variant of the same product. Before ordering, check the name of the selected variant, the declared quantity, and the corresponding price.\u003c\/p\u003e\n\u003ch2 data-peptiva-packaging=\"v12\"\u003eFormat and packaging content\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eResearch dispenser:\u003c\/strong\u003e this variant contains a fully filled dispenser with the selected content, not just a separate replacement cartridge. The quantity specified with the variant refers to the total declared content, not the quantity per individual use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVial:\u003c\/strong\u003e this variant contains research material in a vial, without a dispenser. The packaging name itself does not determine whether the content is lyophilized, in another solid form, or in solution; the declaration of the specific batch is authoritative. This description does not apply to bacteriostatic water or a separate empty container.\u003c\/p\u003e\n\u003cp\u003eStorage and handling conditions depend on the specific formulation and batch declaration. The packaging format does not confirm sterility, dosing precision, stability, or suitability for human or animal use.\u003c\/p\u003e\n\u003ch2\u003eImportant limitations\u003c\/h2\u003e\n\u003cp\u003eEvidence for PE-22-28 is limited and preclinical. The safety and efficacy for human use have not been established.\u003c\/p\u003e\n\u003cp\u003eThe product is not intended for the treatment of depression, anxiety, or other neurological and psychiatric conditions, nor for improving mood, memory, or concentration. It is not a substitute for prescribed therapy. The description does not constitute a recommendation for self-administration or combination with medications.\u003c\/p\u003e\n\u003ch2\u003eBatch Documentation\u003c\/h2\u003e\n\u003cp\u003eFor inquiries about available COA documentation, please contact \u003ca href=\"mailto:peptivacomhr@gmail.com\"\u003epeptivacomhr@gmail.com\u003c\/a\u003e with the product name and LOT number if known. Availability and scope of analyses are checked for the specific batch.\u003c\/p\u003e\n\u003cp\u003eFor interpreting results, the exact identity and sequence of the peptide and the analytical methods used are important. A COA does not inherently prove biological activity, sterility, or suitability for human or animal use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIntended use and limitations:\u003c\/strong\u003e The product is intended exclusively for laboratory research. It is not intended for use in humans or animals, diagnosis, treatment, mitigation, or prevention of disease. The description is not medical advice. The research-use-only label and packaging name do not themselves determine the regulatory status of the product nor prove its safety or sterility.\u003c\/p\u003e","brand":"Peptiva","offers":[{"title":"5 mg \/ Bottle","offer_id":56972272828756,"sku":"PEP-PE2228-5MG-AMP","price":55.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg \/ Research dispenser","offer_id":56972272861524,"sku":"PEP-PE2228-5MG-PEN","price":70.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1046\/2219\/5028\/files\/D94F3449-3F76-4DB1-80DC-98F80136B450.png?v=1788126080","url":"https:\/\/peptiva.com.hr\/en\/products\/pe-22-28","provider":"Peptiva peptides","version":"1.0","type":"link"}