PE-22-28

What is PE-22-28?

PE-22-28 is a short synthetic peptide derived from the 22–28 region of the spadin peptide. It is studied in preclinical neurobiological research, primarily in the context of the TREK-1 potassium channel and the regulation of neuronal excitability.

PE-22-28 should be distinguished from original spadin and its other analogues: results for one compound do not automatically confirm the properties of others.

Mechanism and Scientific Context

TREK-1, also known as KCNK2, belongs to the family of two-pore domain potassium channels. It participates in regulating membrane potential and cellular responses to various stimuli.

PE-22-28 is investigated as an inhibitor of the TREK-1 channel. Altering the activity of this channel can influence the electrical properties of neurons and related signaling processes in experimental systems.

Preclinical work on spadin and its derivatives includes behavioral models related to depression research. Such findings do not constitute proof of antidepressant efficacy of PE-22-28 in humans.

Main Research Areas

• TREK-1 potassium channel and its regulation
• membrane potential and neuronal excitability
• structure-activity relationship of spadin derivatives
• cellular signaling processes related to neuronal plasticity
• preclinical behavioral models related to stress response

How to interpret research data?

Literature on PE-22-28 should be read according to the exact identity of the peptide tested and the type of evidence. Results from electrophysiological experiments, cell cultures, animal models, and controlled clinical studies do not carry equal weight.

Especially important are the peptide sequence, concentration, model used, duration of observation, control group, and independent reproducibility of results. Behavioral changes in an animal model cannot be equated with improved mood or treatment of depression in humans.

Data for spadin or its other derivatives should not be attributed to the PE-22-28 compound without verification.

Available Peptiva variants

• 5 mg · Vial
• 5 mg · Research dispenser

You select the available format as a variant of the same product. Before ordering, check the name of the selected variant, the declared quantity, and the corresponding price.

Format and packaging content

Research dispenser: this variant contains a fully filled dispenser with the selected content, not just a separate replacement cartridge. The quantity specified with the variant refers to the total declared content, not the quantity per individual use.

Vial: this variant contains research material in a vial, without a dispenser. The packaging name itself does not determine whether the content is lyophilized, in another solid form, or in solution; the declaration of the specific batch is authoritative. This description does not apply to bacteriostatic water or a separate empty container.

Storage and handling conditions depend on the specific formulation and batch declaration. The packaging format does not confirm sterility, dosing precision, stability, or suitability for human or animal use.

Important limitations

Evidence for PE-22-28 is limited and preclinical. The safety and efficacy for human use have not been established.

The product is not intended for the treatment of depression, anxiety, or other neurological and psychiatric conditions, nor for improving mood, memory, or concentration. It is not a substitute for prescribed therapy. The description does not constitute a recommendation for self-administration or combination with medications.

Batch Documentation

For inquiries about available COA documentation, please contact peptivacomhr@gmail.com with the product name and LOT number if known. Availability and scope of analyses are checked for the specific batch.

For interpreting results, the exact identity and sequence of the peptide and the analytical methods used are important. A COA does not inherently prove biological activity, sterility, or suitability for human or animal use.

Intended use and limitations: The product is intended exclusively for laboratory research. It is not intended for use in humans or animals, diagnosis, treatment, mitigation, or prevention of disease. The description is not medical advice. The research-use-only label and packaging name do not themselves determine the regulatory status of the product nor prove its safety or sterility.