PEPTIVA PEPTIDES
Research Compound LL-37
Peptiva
FOR IN VITRO LABORATORY RESEARCH ONLY.
Not intended for personal, clinical, diagnostic or veterinary use, or for administration to humans or animals.
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Editorial map of the main themes found in the scientific literature. Bar length is not a statistical score, efficacy rating, or indication for human use.
| Strength | 10 mg |
|---|---|
| Format | Vial · Research dispenser |
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Research Compound LL-37 is a laboratory material for analytical and in vitro work.
LL-37 is a 37-amino-acid peptide beginning with two leucines (hence the name), with a molecular weight of approximately 4.5 kDa. It is the only human cathelicidin, produced by cleavage of the C-terminal part of the precursor protein hCAP18, primarily by proteinase 3.
Human cathelicidin was described in the mid-1990s, a period when antimicrobial peptides were recognised as an important part of mammalian innate immunity. LL-37 has since become one of the most studied human antimicrobial peptides.
In solution LL-37 forms a positively charged amphipathic alpha-helix, allowing it to interact with and disrupt negatively charged bacterial membranes. Beyond direct antimicrobial activity in vitro, it is studied as an immunomodulator: it binds lipopolysaccharide, influences chemotaxis and activates receptors such as FPR2.
Strong mechanistic and preclinical literature. There is no basis for independent therapeutic use of the research material.
Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.
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PEPTIVA PRO E-BOOK · DIGITAL EDITION
The expanded guide covers more than 50 compounds, mechanisms of action, levels of evidence, limitations of the available data and research regimens reported in publicly available scientific literature.
Educational content is not medical advice, a recommendation for self-administration or instructions for using products sold in this store.
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