PEPTIVA PEPTIDES
Research Compound MOTS-c
Peptiva
FOR IN VITRO LABORATORY RESEARCH ONLY.
Not intended for personal, clinical, diagnostic or veterinary use, or for administration to humans or animals.
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Editorial map of the main themes found in the scientific literature. Bar length is not a statistical score, efficacy rating, or indication for human use.
| Strength | 10 mg · 20 mg |
|---|---|
| Format | Lyophilised vial · Research dispenser |
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Research Compound MOTS-c is a laboratory material for analytical and in vitro work, available in 10 mg and 20 mg variants.
MOTS-c is a 16-amino-acid peptide (MRWQEMGYIFYPRKLR) with a molecular weight of approximately 2.2 kDa. It is encoded within mitochondrial DNA, in the gene for 12S ribosomal RNA, which places it among the mitochondrial-derived peptides.
MOTS-c was described in 2015 by Pinchas Cohen's group at the University of Southern California. The discovery was surprising because the 12S rRNA region had long been considered purely structural rather than coding for its own peptides.
In the original work MOTS-c interfered with the folate cycle, leading to accumulation of the intermediate AICAR and activation of AMPK, the central sensor of cellular energy. Later work describes translocation of MOTS-c to the nucleus under metabolic stress and effects on gene expression, making it an example of mitochondria-to-nucleus communication.
Predominantly preclinical, with limited human data.
A related peptide is Humanin; see also SS-31.
Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.
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PEPTIVA PRO E-BOOK · DIGITAL EDITION
The expanded guide covers more than 50 compounds, mechanisms of action, levels of evidence, limitations of the available data and research regimens reported in publicly available scientific literature.
Educational content is not medical advice, a recommendation for self-administration or instructions for using products sold in this store.
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