Research Compound SNAP-8 is a laboratory material for analytical and in vitro work.
What is SNAP-8?
SNAP-8 (acetyl octapeptide-3) is a synthetic octapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 and a molecular weight of approximately 1075 Da. Structurally it extends the hexapeptide known as acetyl hexapeptide-8 by two additional amino acids.
Research background
The sequence was designed after the N-terminal region of SNAP-25, one of the components of the SNARE complex. Most published data originate from formulation and industry literature rather than independent peer-reviewed research.
Mechanism and scientific context
The SNARE complex (SNAP-25, syntaxin and synaptobrevin) mediates vesicle fusion with the membrane and neurotransmitter release. The proposed concept is that a peptide mimicking part of SNAP-25 competitively interferes with complex assembly. This is mechanistically different from botulinum toxin, which enzymatically cleaves SNARE proteins, so comparisons by name do not imply the same mechanism or potency.
Main research areas
- SNARE complex assembly
- peptide–protein interactions
- exocytosis in cellular models
- peptide stability in formulations
Level of evidence
Limited. In vitro and formulation data predominate; independent quality studies are scarce.
Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.