Bremelanotide (PT-141): melanocortin receptor signaling

Bremelanotide, also known as PT-141, is a cyclic peptide associated with the melanocortin receptor system. It is studied in the context of central melanocortin signaling and functional receptor selectivity.

Melanocortin receptors

The melanocortin family contains several G-protein-coupled receptors with different tissue distributions and signaling profiles. The broad term “melanocortin agonist” therefore does not fully describe a molecule's functional profile.

What is studied in vitro?

• affinity and functional activity at individual receptors
• cellular cAMP response
• concentration-response relationships
• selectivity across receptor subtypes
• stability of the cyclic peptide structure

PT-141 and bremelanotide

PT-141 is a development identifier widely used in scientific and online sources, while bremelanotide is the generic molecular name. Scientific interpretation should distinguish the molecule, a regulated pharmaceutical product and a laboratory research material.

Related laboratory material

See the neutrally labeled PT Compound 10 mg laboratory material.

Source

FDA regulatory documentation for bremelanotide

RESEARCH USE ONLY: This educational content concerns laboratory and scientific research. Peptiva research materials are not medicines and are not intended for use in humans or animals.