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GHK-Cu is a complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine with a copper ion, originally isolated from human plasma in 1973.
Why it is an interesting research model
In in vitro research GHK-Cu is used to study fibroblasts, collagen synthesis, the extracellular matrix and dermal cell models. The copper–peptide complex creates a specific research context distinct from pure peptide or metal compounds.
The role of copper in the complex
Copper is an essential trace element involved in many enzymatic reactions, including those related to collagen formation and cellular antioxidant defence. When bound to the GHK tripeptide it forms a stable complex whose biological activity in research models differs from that of the peptide or the copper ion alone, making it an interesting subject for studying coordination chemistry in a biological context.
Extracellular matrix remodelling
In cellular models GHK-Cu is associated with regulation of metalloproteinases and their inhibitors and with collagen and glycosaminoglycan synthesis in fibroblasts. Gene expression analyses suggest an influence on a large number of genes, but such bioinformatic findings do not demonstrate an effect outside the laboratory model.
Available specifications
Peptiva offers GHK-Cu in two amounts — 50 mg and 100 mg — in both laboratory formats (vial and research dispenser).
Combined research preparations
GHK-Cu is also a component of combined preparations such as GLOW, where it is studied alongside other compounds in dermal and tissue research models.
Analytical documentation
As with all catalogue materials, it is essential to check the COA documentation matching the supplied lot before ordering, since literature on the molecule does not confirm the composition of a specific batch.
Related research area
For broader context see the Dermal and follicular models collection.
This article is intended for general research context and does not constitute medical advice or a recommendation for use in humans or animals.