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SS-31, also known in the literature as elamipretide, is a small aromatic-cationic peptide studied in the context of mitochondrial membranes and cellular bioenergetics. Research focuses on its relationship with the inner mitochondrial membrane, cardiolipin and respiratory-chain function.
Why does cardiolipin matter?
Cardiolipin is a characteristic phospholipid of the inner mitochondrial membrane. It participates in the organization of respiratory-chain complexes and membrane architecture. Changes to its structure or oxidation state can influence electron transfer and energy production.
SS-31 research areas
- inner-membrane stability
- respiratory supercomplex organization
- oxygen consumption and ATP production
- oxidative stress and lipid peroxidation
- differences between cellular and isolated-mitochondria models
SS-31 is not MOTS-c
Although both terms appear in mitochondrial research, SS-31 is a synthetic tetrapeptide associated with the membrane context, whereas MOTS-c is a mitochondria-derived peptide linked to cellular signaling responses.
Related laboratory material
See Mito-Peptide SS31 10 mg and the comparison MOTS-c vs SS-31.
Source
PubMed: SS-31 and mitochondrial function
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