PEPTIVA PEPTIDES
Research Compound Humanin
Peptiva
FOR IN VITRO LABORATORY RESEARCH ONLY.
Not intended for personal, clinical, diagnostic or veterinary use, or for administration to humans or animals.
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Full shipping terms →MAIN RESEARCH AREAS Research profile
Editorial map of the main themes found in the scientific literature. Bar length is not a statistical score, efficacy rating, or indication for human use.
| Strength | 10 mg |
|---|---|
| Format | Lyophilised vial · Research dispenser |
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Research Compound Humanin is a laboratory material for analytical and in vitro work.
Humanin is a 24-amino-acid peptide (MAPRGFSCLLLLTSEIDLPVKRRA) with a molecular weight of approximately 2.7 kDa. It is encoded within the mitochondrial gene for 16S ribosomal RNA and was the first mitochondrial-derived peptide to be discovered.
Humanin was discovered in 2001 by Ikuo Nishimoto's group in Japan while searching for genes that protect neurons from amyloid-related toxicity in cellular models. Related peptides such as MOTS-c were found later, creating an entire research field.
Humanin acts both inside and outside the cell. Intracellularly it is associated with inhibition of the pro-apoptotic protein Bax; extracellularly with the FPRL1 receptor and a trimeric receptor complex that includes gp130. The literature also frequently uses the analogue HNG (serine-to-glycine substitution at position 14), which shows greater activity in models.
Predominantly preclinical. Clinical benefit in humans has not been established.
Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.
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PEPTIVA PRO E-BOOK · DIGITAL EDITION
The expanded guide covers more than 50 compounds, mechanisms of action, levels of evidence, limitations of the available data and research regimens reported in publicly available scientific literature.
Educational content is not medical advice, a recommendation for self-administration or instructions for using products sold in this store.
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