Research Compound NAD+ is a laboratory material for analytical and in vitro work, available in 500 mg and 1000 mg variants.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide, oxidised form) is a naturally occurring coenzyme present in all living cells, not a peptide. It consists of two nucleotides joined by phosphate groups, with a molecular weight of approximately 663 Da.
Research background
NAD+ was described in 1906 by Arthur Harden and William Young as the “cozymase” required for fermentation in yeast. Its structure and role in electron transfer were later clarified by Hans von Euler-Chelpin, who shared the 1929 Nobel Prize in Chemistry for this work.
Mechanism and scientific context
The NAD+/NADH pair carries electrons in glycolysis, the citric acid cycle and oxidative phosphorylation. NAD+ also serves as a consumed substrate for enzymes that break it down: sirtuins (deacetylases), PARP enzymes (DNA repair) and CD38. The balance between synthesis and consumption determines cellular NAD+ levels.
Main research areas
- redox metabolism and the NAD+/NADH ratio
- mitochondrial bioenergetics
- sirtuins and PARP enzymes
- NAD+ biosynthetic and degradation pathways
Level of evidence
The biochemical basis is very strong. Broad claims about the effects of additional NAD+ have not been adequately confirmed.
Related
Related materials include 5-Amino-1MQ, MOTS-c and SS-31.
Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.
Available COA documentation
Manufacturer documents listed in Peptiva’s public collection:
Before ordering, confirm that the document lot matches the currently available batch, quantity and format. A document for one batch or format does not establish the properties of another. Contact Peptiva to confirm documentation for the selected variant.
All available Certificates of Analysis