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Research Compound Adipotide
€51,00
Sale price
€51,00
Regular price
€60,00
FOR IN VITRO LABORATORY RESEARCH ONLY.
Not intended for personal, clinical, diagnostic or veterinary use, or for administration to humans or animals.
MAIN RESEARCH AREAS Research profile
Editorial map of the main themes found in the scientific literature. Bar length is not a statistical score, efficacy rating, or indication for human use.
Description and specifications
Research Compound Adipotide is a laboratory material for analytical and in vitro work.
What is Adipotide?
Adipotide (also known as FTPP, prohibitin-targeting peptide 1) is a synthetic peptidomimetic composed of two functional parts: a cyclic CKGGRAKDC motif that binds prohibitin on the endothelium of adipose tissue blood vessels, and the pro-apoptotic sequence D(KLAKLAK)2, which disrupts mitochondrial membranes.
Research background
The molecule was developed by the group of Renata Pasqualini and Wadih Arap at MD Anderson Cancer Center, using phage display to identify peptides that selectively target the blood vessels of specific tissues. Results in mice were published in 2004 and in primates in 2011.
Mechanism and scientific context
The concept is based on vascular targeting: rather than acting on adipose cells directly, the peptide binds to the endothelium that supplies them and induces apoptosis of those cells. The primate study also described effects on renal function, an important part of the molecule's safety profile.
Main research areas
- vascular targeting with peptides (phage display)
- prohibitin as a vascular marker
- apoptotic signalling
- adipose tissue vasculature
Level of evidence
Exclusively preclinical. Effects on the kidneys were also described in animal models. Quality human data are not available.
Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.
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The expanded guide covers more than 50 compounds, mechanisms of action, levels of evidence, limitations of the available data and research regimens reported in publicly available scientific literature.
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- Experimental approaches described in scientific literature
- COA, purity and documentation
Educational content is not medical advice, a recommendation for self-administration or instructions for using products sold in this store.
COA on request
To enquire about a certificate of analysis (COA), send the material name, requested variant and LOT / batch number if available. Documents are not published on this page.
Request a COA by emailThe button opens your email app with a prepared enquiry. You send the message yourself. peptivapeptides@protonmail.com
A COA applies to a specific batch and documents the analytical parameters tested for that batch. The product is intended strictly for laboratory, analytical and in vitro research.