Research Compound Oxytocin is a laboratory material for analytical and in vitro work.
What is oxytocin?
Oxytocin is an endogenous nonapeptide with the sequence Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2, a disulfide bridge between the two cysteines, and a molecular weight of approximately 1007 Da. It is synthesised in the hypothalamus and released from the posterior pituitary.
Research background
Oxytocin was the first peptide hormone to have its structure determined and to be chemically synthesised. For this work Vincent du Vigneaud received the 1955 Nobel Prize in Chemistry, opening the way for modern peptide chemistry.
Mechanism and scientific context
The oxytocin receptor (OXTR) is a G-protein-coupled receptor that signals primarily via Gq, phospholipase C and a rise in intracellular calcium. The receptor is present in smooth muscle, the central nervous system and other tissues, so the system is studied in very different experimental contexts.
Main research areas
- OXTR receptor pharmacology
- Gq and calcium signalling
- smooth muscle contractility in models
- neuroendocrine signalling
Level of evidence
The physiology is very well studied, and regulated medicinal preparations have extensive documentation. This is not evidence of the properties of this research material, whose identity is confirmed only by batch documentation.
Related
See also Kisspeptin and the Reproductive endocrinology collection.
Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.