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KPV 10 mg lyophilised vial — Peptiva product image
  • KPV 10 mg lyophilised vial — Peptiva product image
  • KPV 10 mg research dispenser — Peptiva product image
Research Compound KPV

Peptiva

Research Compound KPV

€46,75
€46,75 €55,00
Strength10 mg
Format

FOR IN VITRO LABORATORY RESEARCH ONLY.
Not intended for personal, clinical, diagnostic or veterinary use, or for administration to humans or animals.

MAIN RESEARCH AREAS Research profile

Imunološka signalizacija Primary
Protuupalni modeli Very common
Modeli cijeljenja tkiva Common
Gastrointestinalni modeli Secondary

Editorial map of the main themes found in the scientific literature. Bar length is not a statistical score, efficacy rating, or indication for human use.

Description and specifications

Research Compound KPV is a laboratory material for analytical and in vitro work.

What is KPV?

KPV is the tripeptide lysine-proline-valine (Lys-Pro-Val), with a molecular weight of approximately 342 Da. It corresponds to the C-terminal portion (positions 11–13) of alpha-melanocyte-stimulating hormone (α-MSH), a 13-amino-acid peptide of the melanocortin family.

Research background

Studies of α-MSH showed that part of the hormone's anti-inflammatory activity in experimental models is retained in this short C-terminal fragment. This prompted separate study of KPV as a minimal active sequence, independent of the pigmentation-related effects of full-length α-MSH.

Mechanism and scientific context

In cellular models KPV is associated with inhibition of NF-κB and MAPK signalling and reduced production of pro-inflammatory cytokines. Work on intestinal epithelium describes cellular uptake of KPV via the PepT1 transporter, studied in animal models of intestinal inflammation. The precise receptor mechanism has not been fully elucidated.

Main research areas

  • NF-κB and MAPK signalling
  • cytokine response
  • intestinal epithelium and the PepT1 transporter
  • epithelial barrier
  • gastrointestinal animal models

Level of evidence

Predominantly preclinical. Data come from cellular and animal models; there is no evidence of clinical efficacy in humans.

Related research materials

KPV is a component of the combined preparation KLOW.

Research use only: for laboratory, analytical and in vitro research only; not for use in humans or animals. Guidance on batch documentation is available in our COA guide.

Peptides Without Myths — Scientific Handbook (PDF)

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The expanded guide covers more than 50 compounds, mechanisms of action, levels of evidence, limitations of the available data and research regimens reported in publicly available scientific literature.

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  • Preclinical and clinical data clearly distinguished
  • Experimental approaches described in scientific literature
  • COA, purity and documentation

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Educational content is not medical advice, a recommendation for self-administration or instructions for using products sold in this store.

COA on request

To enquire about a certificate of analysis (COA), send the material name, requested variant and LOT / batch number if available. Documents are not published on this page.

Request a COA by email

The button opens your email app with a prepared enquiry. You send the message yourself. peptivapeptides@protonmail.com

A COA applies to a specific batch and documents the analytical parameters tested for that batch. The product is intended strictly for laboratory, analytical and in vitro research.

Related research areas

Gastrointestinal models Immune signalling Tissue and vascular models Full research catalogue How to read COA documentation

Other catalogue materials
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A
Anonymous

Ponovno naručujem čim potrošim ovo pakiranje.

A
Anonymous

Sve uredno označeno i dobro zaštićeno.

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Anonymous

Prvi put naručio KPV i jako zadovoljan cijelim procesom kupnje.

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Anonymous

KPV + BPC. Odlična komunikacija.

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Anonymous

Napokon pronašao KPV kod nas. Sve stiglo bez problema.